We got a full on trailer last night from the VGAs. Now, I've only just completed the main game. In it, Mr Scratch came out of left field, and was gone two seconds later. From what I know, he's a focus in at least the second DLC for the game though. It seems like American Nightmare might be a direct continuation of the first game's story (contrary to what's been said up until now).
The down side? This trailer leaves me to believe that this is small game is going to be action heavy. Fans of the game will agree that towards the end of the game, we put up with the combat just to see what happens in the story. I myself ended up playing the back half of the game in like one hour chunks every few days because the combat became such a chore. But, we do see the addition of a small, MAC10 like sub-machine gun in the trailer, so hopefully they've made things better.
(Note: the audio in the trailer becomes off-sync about half way though.)