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They may be good or evil, but mad scientists are always performing experiments that are on the outer fringes of science. Ever since Mary Shelley's Frankenstein, they've been in the scene.
The ability to influence and control the thoughts of others.
Not all scientists are mad and/or hell-bent on dominating worlds. Some are just your ordinary egghead with a coat.
In the Mass Effect franchise, the Reapers are a hyper-advanced machine race that appear periodically every 50,000 years to bring a close to a "cycle" in which the Reapers harvest all the advanced forms of life.
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