Source: Runner 2 Blog

PS3

For technical reasons, we had to remove a few features from the PS3 version: depth of field, shadow filtering, and micro leaderboards at the end of every level. As a result of having no depth of field, the game is sharper and colors more vibrant.

Steam (Windows, OSX, Linux)

Because they run on a PC, the Steam versions are the most configurable, but also the most volatile: the game is only as good as your computer. And let's be clear: this game was designed to be played with a gamepad. If you don't have a wired Xbox 360 controller, you will still be able to play the game using the keyboard, but the gamepad controls are much more intuitive!

Steam also makes it easy to stay up to date with the latest fixes.

Wii U

The clear difference with the Wii U version is that you can play the entire game on either your gamepad or your TV. Also, because it is the newest platform with the most memory, it has the best overall load times of any of the consoles. Initial loading may be a bit slower, but it speeds up as you play since we can keep more content in memory, which means fewer loads overall.

Xbox 360

The Xbox build has the slowest load times of the consoles. It's possible we will be able to speed this up in a future update.