Just saw a feature on Borderlands 2 last night on TV. It sounds dirty, but Money Shots are now present in Borderlands 2. Doing critical damage with the last bullet in your clip. Seems pretty useful for boss fights.
Also, the city of Sanctuary seems like a good idea. Doing what other RPGs are famous for, and giving players a central hub where they can learn all about the backstories and what not seems awesome. I'll probably spend lots of time at the beginning exploring Sanctuary.
The preview made me want to play this game SOO much more...hurry up September 18th.