So I play a lot of video games of all kinds. I can't think of another game ever that has given me a headache or made me feel sick simply from playing it. However this happens about an hour in every time I play Borderlands. Maybe it has something to do with the vivid art style? That's not to say I don't love the game, I still play it, I am just not able to marathon play it at anytime.
 
So does anyone else get this when they play Borderlands? Or is there another game that you can't take in large doses?

Nope.

I think art style does have a big role in it. I have trouble with really bright, flashy animations against dark backgrounds. Games like Geometry Wars and Beat Hazard will wear me down pretty fast.

Nah.  I used to get headaches from medal of honor though.  Not sure why.

Ditched the game after the first 2 boss battles but no it didnt cause any headaches. sorry to hear get well soon xoxoxox

It's probably motion sickness.  Take some Dramamine.

Not me.

Motion sickness accompanied by the FOV, I get it with certain games too.

No but I have a killer headache right now.

I haven't played an FPS in quite some time, but when I got back into TF2 I had some serious headaches, especially with Scout my favourite class

" So I play a lot of video games of all kinds. I can't think of another game ever that has given me a headache or made me feel sick simply from playing it. However this happens about an hour in every time I play Borderlands. Maybe it has something to do with the vivid art style? That's not to say I don't love the game, I still play it, I am just not able to marathon play it at anytime.  So does anyone else get this when they play Borderlands? Or is there another game that you can't take in large doses? "

It messes with my head and I've played first person games for years and this is the only game that has ever effected me! still love it myself though

I played it while sick and I never got a headache or anything.

I get headaches from the Battlefield games. 

Never had a problem like yours playing any game. They only game that kind of messes with me is geometry wars, all those flashes are really hard on your eyes.

Never. Even Beat Hazard, which is much harsher in its flashing than geometry wars, stopped bothering me after maybe fifteen minutes of playing it the first time. My brain just figured out how to filter out the noise, I guess.

The same thing happened to me... sort of.
 
I've never experienced any kind of motion sickness due to a game, but for some reason when I first started playing Borderlands I found the game disorienting (even though I play a ton of FPS) and got a bit of a headache.  This only happened the first time I played it, and only lasted an hour or so.  I ended up finishing the game without any further problems.  I guess I acclimated to the art style or something.

Must be the radiation.

I tend to get quite gaseous while playing borderlands, is this normal?

" It can make me feel drowsy, but no headaches. "

" It's probably motion sickness.  Take some Dramamine. "

i got a headache as soon as it arrived in the mail today.

Actually, yes, now that you mention it. I did get several headaches playing Borderlands, more so than with other games at the time. But that might be because I played Borderlands for longer stretches, usually 1.5-3 hours at a time in a 3-player Co-Op game.

Not really. I rarely get them because of games, I just get a lot of them in general.

When I played Borderlands for the first time, my entire family died. There sure is something about that game.

I would get constant headaches while playing GTA 4. The greasy, blurry graphics really are painful to look at after a while.

" It can make me feel drowsy, but no headaches. "

@mazik765: Oh yes my friend, I thought I was the only one but I also get very sick and have headaches if I play Borderlands for a long time. I don't know why and I really like the game. Unfortunately some games do that to me. Medal of Honor as someone said, GTA and Saints Row games etc. Right now I still have a headache from Bordelands

It hasn't happened with Borderlands and I played that for some really long stretches. Although, something similar did happen with the original Darksiders, but that was more a nausea/dizziness type thing.

100% YES! I get headaches after 20 mins of playing, every time with Borderlands. There's also a slight drowsy effect that kicks in after extended sessions. Stop playing the game after an hour they're gone. Only other game that did the same was Perfect Dark Zero. I play a shit ton of games and never experience these symptoms with any other game. At first I thought it was the low frames per second in first person view, but now I really do think it's the cartoony art style in FP view that does it.... I'm gonna have to soldier on with BL2, for gamings sake...