Brad abandoned his teammates once he witnesses the death of Joseph Frost in the woods of Arklay Forest. He tries to contact the player while flying around the Arklay mountains. In the final battle with the Tyrant, he defies his nickname by showing up to toss the player a rocket launcher that is needed to kill the Tyrant. In both the original Resident Evil and its remake, Brad is never actually seen in person and is only heard while he's piloting the helicopter.
Brad plays no part in the main storyline, but does make a special cameo appearance as a hidden zombie. No explanation was given as to how he met his end, but it is eventually revealed that he reawakened from the t-virus infection he suffered from the Nemesis in Resident Evil 3 (see below).
He is found wandering around the R.P.D. headquarters if the player makes it there, from the beginning in the Raccoon City streets, without picking up any items during Scenario A. Brad has more stamina than a regular zombie, however, but killing him rewards players with a special key. The key can then be used to open the wardrobe locker in the Police Department's Dark Room and lets players change Leon and Claire's outfits.
Leon unlocks two different outfits, whereas Claire only unlocks one. However, Claire is instead gifted a 6-shot revolver exclusive to her, to tie in with the cowgirl theme of her alternate costume. Leon, while he doesn't obtain a new weapon, will now wield handguns sideways with one hand; this stance then gives Leon increased firing speed with handguns, though can be only be used while wearing one of the alternate costumes.
If players manage to trigger the appearance of zombie Brad in Scenario A, he will then show up once again in the same location in the alternate character's Scenario B without any other prerequisites.
Brad discovers off-screen that the S.T.A.R.S. members were being targeted by a powerful abomination known as the Nemesis, Umbrella's newest Bio-Organic Weapon. He warns Jill Valentine about the creature's presence in Raccoon City before being killed by it at the front gate of the Raccoon City Police Department before her eyes. When Jill leaves the police station, Brad's corpse will have disappeared.
In the N64 version, there's an exclusive document in which Brad describes his encounters with Nemesis. It reads as follows:
No!! It's that monster in the black suit again! Why does that thing keep chasing me?! What did I do? This must be someone's sick idea of a joke. If I knew things were going to end up like this, I would have left the S.T.A.R.S.team a long time ago. But whining won't help me now. I know I'm finished...
Oh... In my hometown Delucia, I bet the flowers are in bloom. If I could only see them once more before I die...
- When first encountered in J's Bar, Brad will respond to Jill differently--either relatively more friendly or hostile--depending on whether the player chooses to help fend off the zombie attacking him or not.
- Brad is featured in Resident Evil 3's minigame, Mercenaries: Operation Mad Jackal. He is one of the ''hostages'' that the player can save, located in the restaurant basement.
- While it's possible he could be using a different pistol, Brad Vickers' handgun shares the same firing sound effect as the SIGPRO, which is the standard issue pistol for UBCS soldiers during Resident Evil 3.
- Finding out how to trigger the appearance of zombie Brad in Resident Evil 2 was done by completing any scenario for either character with at least an A rank.