Claire Redfield

Resident Evil 2

Claire enters Raccoon City on the same night as Leon Kennedy, only a day or so after the initial viral outbreak has begun. Searching for her brother Chris, who has been missing since the Special Tactics and Rescue Service were suspended from duty after they claimed that the Umbrella Corporation had been creating bio-weapons in the abandoned Spencer Estate outside of the city.

Taking a peek inside Emmy's Diner--a frequent dining spot for her brother, who lacks cooking skills--Claire is quickly assaulted by the living dead. Fleeing to a back door, she is rescued by Leon, and they both seek safe haven in an abandoned patrol car.

Or so they thought. The officer who had been in the back seat all along reanimates into a zombie and attacked Leon, causing a car crash and the subsequent explosion of the patrol car, separating Leon and Claire from one another.

In the police station, Claire is stalked by a large Bio-Organic Weapon that she refers to as Mr. X.  X is repeatedly defeated by Claire, but regenerates over time and continues his slow chase. Claire encounters him a number of times through the course of the game.

As the game progresses, Claire encounters police chief Brian Irons, who believes her to have been contracted by Umbrella to assassinate him. Irons is attacked by the G-Mutant William Birkin before he can kill Claire, and William indirectly saves his own daughter by allowing Claire to escape into the sewer network with the young Sherry Birkin. Claire comes up against William Birkin in the sewers, but dispatches the weakest of his G-Mutations with ease.

Sherry is accidentally sucked into a sewer drain where, while unconscious, she is implanted with a G-Virus embryo by her father. Claire does everything she can to recover the girl, and eventually encounters the girl's mother Annette, who had just fallen over a sewer railing after wrestling with Ada Wong. Convinced that everyone is out to get her and William's life's work, Annette doesn't believe Claire when she asks for her help in locating Sherry.

Claire eventually finds Sherry but realizes that she must have been infected.  Annette finally belives Claire and is killed by her deformed husband that no longer recognizes her.  Annette's final act is to give claire the means to cure her only daughter.  Claire has several more encounters with the G-Virus infected William Birkin until she defeats him (or so she thinks).  Climbing aboard the train and starting the engine, Claire spots Leon Kennedy as he approaches the train and calls for him to hurry up and jump on. Despite her vision of Leon being blocked by a concrete beam, she is relieved when he stumbles in through one of the train compartment doors.

Just when the trio think that they are safe the final mutation of William Birkin, reduced to a blob with eyes and tentacles, sets off the bio-hazard alarm on the train. Unable to defeat him due to the regenerative properties of the G-Virus, Claire flees and activates the self-destruction mechanism on the train. Claire, Leon and Sherry escape the train just in time, and the girl vows to find her brother.

Resident Evil Code: Veronica X

Claire leads a one-woman assault on the main headquarters of the Umbrella Corporation, but is ultimately captured and sent to Rockfort Island shortly before it is attacked by the Agency and yet another T-Virus outbreak occurs.

During the game, Claire meets Steve Burnside, a young boy looking for his father who works on the island. She sends out a call for help over the internet, relaying a message to Leon Kennedy, which is quickly relayed from Leon to Chris Redfield.

While assisting Steve, the two of them do eventually come across his father, who has been transformed into the living dead by the T-Virus outbreak. Though hesitant, Steve kills his father and has a break-down immediately afterward. 

Through the game, Claire's progress at escaping yet another hellish zombie outbreak is hindered even further by Alfred Ashford, the insane Umbrella Corporation executive in charge of the island. Alfred constantly causes problems for Claire and Steve, sealing them inside of rooms and taking pot-shots at them when they aren't paying attention or when the situation favors him.

Before gaining access to Alfred's private mansion, Claire is confronted by Albert Wesker. It is revealed that Wesker lead the assault on Rockfort that released the T-Virus. Wesker proclaims his hatred for Chris Redfield and decides to eliminate Claire, demonstrating his newfound super-human abilities. He is summoned away before he can finish the job, and leaves Claire with one more thing to worry about.

Hoping to escape both Alfred Ashford and Albert Wesker, and the subsequent self-destruction sequence, Claire and Steve board a automated flight to Antarctica, leading them into yet another hellish zombie nightmare only after facing a Tyrant on the plane.

Claire and Steve retreat into the Umbrella facility and are quick to discover that Alfred has followed them. Aware that he can't win against them using his own personal skill Alfred releases his father, now the dreaded creature Nosferatu, who turns on him and kills him. Claire and Steve successfully destroy the monster, but are taken into captivity by Alexia Ashford, Alfred's sister.

Chris Redfield arrives in Antarctica soon enough, hastily chasing his former S.T.A.R.S. Captain. He rescues Claire, but Steve is a lost cause, infected by Alexia's T-Veronica virus. He dies in front of Claire and her brother.

Trying to escape, Claire and Chris happen upon an ensuing battle between Alexia and Wesker. Wesker takes his leave, jokingly referring to Chris' killing of Alexia as an "order." Chris destroys Alexia, and the disgruntled Wesker takes Claire into captivity. Chris gives chase, and the two former comrades battle each other, Wesker fully demonstrating his new abilities.

Chris is able to outsmart his former captain, dropping several tons of steel onto him. Wesker emerges, barely scathed, but takes his leave with the body of Steve Burnside from whom he can extract a sample of the T-Veronica virus.

Claire escapes the island with Chris.