Not Borderlands 2, rather a topdown dualstick shooter - with loads of loot, and max destructible environments. Kinda like Rambo First Blood Part II, just not on the C64. Bioware only needs to retool the upcoming C&C Generals 2 for such a thing - how about it EA?
Kinda bummed about how Diablo 3 forces my upstart Barbarian more and more into defensive builds, because survival is about skill synergy and stats, rather than movement and active blocking/dodging - and I always think how much better Diablo 3 could be, with movement being independent of aim, dualstick shooter style. Instantly made me think of Commando, but that's an auto-scroller - which made me think of Rambo.
I can scarcely imagine how awesome a game following a modernized C64's Rambo-template would be, if you'd mix in some Diablo-style loot festivities. Anyways - watch the longplay and imagine a world, where just that happens! The imminent rambofication of Diablo! Golden AK-47! Epic Blue Light!