Fire Chains, Invulnerable Minions, Fast. As a Monk. Extra fun if it's one of those small spiders, which are already pretty fast to begin with, and can be hard to target the main one.
Arcane is probably the one attribute that has killed me the most times, though my relationship with that attribute is... complicated. It's interesting, but it can be avoided, at least.
Combinations of Plagued, Molten, Fire Chains and Desecration is also fun... then there's walling, nightmarish, jailer which is naughty in their own ways.
Teleport, Frozen, Horde, Illusionist, Mortar hasn't really been issues for me so far.
Then again, I'm probably going to abandon my monk for a ranged class (wizard?), because Act 2 Inferno is... not fun. Looking forward to hating new combinations! :P
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