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Black Cat is a sometimes burglar, sometimes hero, friend and former lover of Spider-Man. She gains her abilities from a combination of magic and science.
Daredevil is a Marvel comic book superhero whose blindness is off-set by his other four senses being enhanced to superhuman levels. In his civilian identity, he is a professional lawyer.
The "merc with a mouth" is an antihero from the Marvel Universe. Once part of the Weapon X program, Deadpool has a healing factor that allows him to heal from any wound, and uses high-tech equipment and is known for his dark humor and wisecracks. "Maximum effort!"
Doctor Strange Is the current Sorcerer Supreme of the Marvel Universe. He gains his powers from his cape (the cloak of levitation) and his magic amulet (The eye of aggamotto)
Francine Frye was an obsessive supervillain fangirl who became the second Electro.
One of Spider-Man's first girlfriends. In some universes, she is also known as Spider-Gwen. She has been portrayed by Bryce Dallas Howard, Emma Stone and Hailee Steinfeld in various films.
Real name Mark Grayson, he is the half-Viltrumite son of the villainous Omni Man, and is trying to make it as a superhero.
The editor-in-chief of the Daily Bugle in Spider-Man games. Has an agenda against the wall-crawler. He is portrayed by J.K. Simmons in the Sam Raimi Spider-Man Trilogy and the Marvel Cinematic Universe.
Kaine is one of the many clones of Spider-Man. He was a noted serial killer until he was resurrected during the events of Spider-Island. Afterwards he turned over a new leaf and became the new Scarlet Spider.
Karn is a member of the Inheritors, a family of otherworldly beings who hunt down "totems" - people who represent specific members of the animal kingdom.
Lady Spider is a steampunk superhero from the year 1895.
Scorpion is a nemesis of Spider-Man. He was once private investigator Mac Gargan, until J. Jonah Jameson hired him to be the subject of an experiment that gave him immense strength, a costume with a tail that fires lasers, and the deep-down crazies. He was the third Venom.
A red-headed woman who frequently acts as partner to Peter Parker's Spider-Man.
Spider-Man's beloved aunt, May Parker.
Peter Parker's classmate/friend/love interest in the Marvel Cinematic Universe. She is that universe's equivalent to Mary Jane, Spider-Man's usual love interest.
Miles Morales is the new Ultimate Spider-Man, after Peter Parker died in a shark-jumping battle with the Green Goblin. He has almost the same exact powers as Peter Parker, plus bioelectricity and invisibility.
Morlun is the most prominent member of the Inheritors, a family of otherworldly beings who hunt down "totems" - people who represent specific members of the animal kingdom.
The Green Goblin is Norman Osborn, a businessman and scientist who injected himself with an experimental serum to test it. The serum granted him immense strength, but also drove him insane. He is considered the arch nemesis of Spiderman. He is known for using his glider and pumpkin bombs.
After being bitten by a radioactive spider during a science exhibit unrelated to school, timid teenager Peter Parker becomes the Amazing Spider-Man. Armed with the ability to climb walls and enhanced strength, Spider-Man uses his powers to fight evil and protect the innocent.
Monica Rambeau is a police officer-turned superheroine who has used many monikers including Captain Marvel, Photon, and Spectrum.
The Punisher is a vigilante in the Marvel Universe. After the death of his family at the hands of the mafia, Frank Castle becomes The Punisher, dedicated to fighting crime with lethal force.
Dr. Octopus tried to take over New York City with a few other supervillains, but Sackboy stopped him.
Scarlet Spider is a character in the Marvel Comics universe. He is a clone of Peter Parker and goes by the name Ben Reilly. He has also been called a brother of the real Spider-Man.
She-Hulk is a super-heroine in the Marvel universe. She gained her powers from a blood transfusion with her cousin, Bruce Banner, aka the Hulk.
Mob boss and enemy of Spider-Man.
Spider-Girl is a character from the Marvel Comics universe (MC2). She is the daughter of Peter Parker and Mary Jane Watson.
Spider-Pig, Spider-Pig, does whatever a Spider-Pig does.
Alternate reality Spider-Man set in the 1940s. He was voiced by Nicholas Cage in Spider-Man: Into the Spider-Verse (2018).
Spider-Woman is a superheroine in the Marvel Universe. She has superhuman strength and endurance, and the ability to fire bio-electric "venom blasts."
Charlotte Witter was the granddaughter of Madame Web, and an evil Spider-Woman created by Dr. Octopus.
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