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An arcade port on the Genesis, Dynamite Duke has the player assuming the titular role, playing a cybernetically enhanced super-soldier fighting waves of baddies. Battling your way to defeat a turncoat scientist creating an army of mutants, Dynamite Duke was a over-the-shoulder rail shooter. Armed with a MAC-10 and cybernetic arm, Duke shot and punched his way through the game's levels, as it offered both shooting and hand-to-hand action.

An updated version of Dynamite Duke with simultaneous multiplayer was released to arcades under the name "The Double Dynamites."

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