I'm tied between "I'm gonna beat you like a red-headed stepchild!" and "Up yours and have a bullet breakfast, asshole!"

I love 'em both because they summarise the ridiculous humour in Fallout.

"mike like ears" by a black boxer in new reno.

"God I wish I had a limit break..."
Good ol' Cassidy.

Just about anything Sulik says.

"Missy, you've got some explainin' tuh do."

Same as Delsaber, pretty much everything Sulik says.

I admit, I cheated and hit up google for quotes to post here. Some of the stuff I found I just can't imagine being in a game. And I mean in any game Today. How old is this? Ten years? It's still edgy.

Renesco: Me? I'm jolly ol' Saint Nick. And YOU must be that stupid slip of porno trash that trench coat-wearing elderly men use to fulfill their masturbatory fantasies.
Mason: Well, check out this bouquet of assholes.
Myron: Hey, don't use that shit on me! Save it for addicts!

And than all those Hidden Quotes in the Credits. That Team was pretty funny and very dirty. I found a video of them on gametrailers.com and just picked out some random.

Tom F: Cancer, stay away from my penis!
Chad A: I seem to be doing better as a woman.
Danny M: Don't Give Sulik flares cause he'll chuck them like the president's seed.