I played loads of Relic's Warhammer 40k games this year. Started off with Space Marine, then went with Dawn of War & addons, and am currently playing Dawn of War 2. I absolutely love the setting, and Relic quickly became one of my all-time favorite developers. I'll definitely have to play Company of Heroes soon.
Back ontopic - I'd love a Battlefield-style Warhammer 40k online multiplayer game. That'd could potentially be the best thing ever. I heard Vigil's Warhammer 40k MMO moved away from being a MMO - it likely will turn out to becoming just that - a Warhammer 40k Battlefield game. Vigil has already proven to be competent at cherry picking great mechanics from other games with Darksiders, and Darksiders 2 is revving up to being a world series winning homerun this August. I'm confident this will happen, and that it won't suck!
What about you guys? What setting and genre combination do you clamor for?