Game Informer on Assassin's Creed

If you wait long enough on the end of the Assassin's Creed 2 teaser, you'll see a backwards message, that if flipped reads: Game Informer 4/16/09.

Funny.  That's a day after Da Vinci's birthday.

I think we can be sure of where and when the game is taking place.  I heard about it from somewhere before the teaser hit, AND it fits the whole Da Vinci Code-hype that Assassin's Creed also fit perfectly into.