Has a game ever made you cry before?

Yep... Ending of MGS4 and Valkyria Chronicles. 
 
MANLY TEARS!

The ending of MGS3 
  
Like a little bitch 
 
 
Also the ending to Duck Hunt was pretty brutal 
 

Nope. Maybe I'm just playing the wrong games but I don't really feel any kind of emotion in games. Like I might think 'that is sad' but I don't actually get sad. 
 
I smiled at the end of Uncharted 2. That's about it.

This isn't a fucking joke by the way. I am 100% serious.
  

if you mean in frustration? 
 
then yes, Vanquish on godhard. 
 
 
Real tears? 
 

A bit at the end of Layton 3, as much as I don't like to admit it. :|
Can't remember any other times off the top of my head.

" Yep... Ending of MGS4 and Valkyria Chronicles.  MANLY TEARS! "

" 'Snake... had a hard life.'  ;_____________________; "

" Nope. Maybe I'm just playing the wrong games but I don't really feel any kind of emotion in games. Like I might think 'that is sad' or but I don't actually get sad.  I smiled at the end of Uncharted 2. That's about it. "

Not yet. I'm a damn man I never cry. 

At the end of Okami, but that was a mix of joy and sadness. I was happy because it all ended good, and in a beautiful way, but at the same time I was sad that it had to end.  
 
Yes, I am a girl :'(

" At the end of Okami, but that was a mix of joy and sadness. I was happy because it all ended good, and in a beautiful way, but at the same time I was sad that it had to end.   Yes, I am a girl :'( "

I have cried a few times (but I'm a total sap haha) but not often. I just normally get that lump in my throat and I just kind of hold back the tears.
One game that made me cry was .... Legend of Dragoon.... a certain scene in the first disc killed me.

Final Fantasy VI almost made me, and not in any of the areas you'd expect.

I can't get as emotionally invested in games as i can in movies. Lifeless video game eyes don't help.

By the end of Digital: A Love Story I was close to having an emotional breakdown.

" Final Fantasy VI almost made me, and not in any of the areas you'd expect. "

I haven't really cried in years. Maybe teared up.

" The ending of MGS3 
  
Like a little bitch 
 
 
Also the ending to Duck Hunt was pretty brutal 
 
"

I've cried out of fear if that counts.

so many times I can't believe it 
 
Shin Megami Tensei: Strange Journey (neutral ending), Persona 4 (you know the scene), Nier (4-5 times, natch)

"The ending of MGS3 
  
Like a little bitch 
 
 
Also the ending to Duck Hunt was pretty brutal 
 
"

Nope. Never. It's probably because I'm a sociopathic robot. Or maybe an autistic sociopathic robot. Or maybe I don't play the right kind of games.

" 'Snake... had a hard life.'  ;_____________________;   

A number of games have made me tear if, if not outright cry.  Metal Gear Solid 4 and Valkyrie Profile are two that I could name off the top of my head, and most recently Dragon Quest IX.

Ending of MGS3.  The ultimate fuck you ending. The game literally robs you of any feeling of success or accomplishment. Yeah, you beat the game, but you didn't win. You only feel used and a little depressed.

Overlord for Mass Effect 2, I was shocked by the ending, and what they did to that guy really got to me because I have personal experience with autistic kids. Very sad, but I didn't cry.

" Persona 4 (you know the scene) "

....yes. 
 
  

um...I felt emotional at the end of the endurance run I think and maybe at the end of red dead as you go after Abigal and maybe the credits but don't think I cried

The most recent example that pops into my head is Red Dead. 
All the shit Marston goes through and the result of it all. 
I didn't actually cry, and I don't remember crying at a game.  
But I've come damn close.

No, but a certain part of Persona 4 had me close.

" Final Fantasy VI almost made me, and not in any of the areas you'd expect. "

Yeah, when @PixelPrinny kept killing me over and over again on Street Fighter. 

Game? Not that I can remember. An anime got me though. That was surprising.

Walking home at the end of Earthbound.

Personally, I've never cried... but maybe one of the most emotional endings I've ever seen was to Shadow of The Colossus... 
 
...some fucked up shit happens there...

Nope. 
 
It's a fact that speaks to how far video-game narratives still have to go; I'm not afraid to admit that I've cried a couple times upon finishing certain books and films. 
 
But no, I've never cried in response to a video game.

Never really, but the closest I've come is probably in Gears 2 with Dom's wife. I know. Still not quite sure why, just seemed pretty effective at the time.

Final Fantasy VII 

nearly 

I got very, very close in Persona 4, MGS4, and Digital: A Love Story. The only games that ever get me in that sort of mood are ones where I'm super invested in the characters and really care about their ordeals, which, frankly, doesn't happen a whole lot. MGS4 is probably the closest of the lot to making me cry, simply because in that scene, you're not just watching it unfold, but directly participating in it. As Kowbrainz also mentioned, I found the ending for the third Layton game to be surprisingly depressing and poignant, which I wasn't expecting, considering the series' overall lighthearted tone. It doesn't feel out of place in that game, but I was certainly expecting some aspects of that ending to pan out more happily for the cast than they actually did.
 
@cjmabry: By the way, I made this Photoshop in response to another thread about the arbitrary nature of inserting achievements into climactic RPG moments. You'll probably either appreciate it or completely hate me for it.
 

SPOILER WARNING: Click here to reveal hidden content.

 

  
Don't say I didn't warn you.

Considering how awful game stories usually are, no, I never cried.

I got really teary eyed when you play as the female protagonist in Persona 3, get your max social link with Shinjiro only to have him get shot and fall into a coma. It was my first time playing Persona 3 so it was really surprising building up a warm relationship and having him get shot :(

The ending to Final Fantasy X got me mighty close.

I don't get people crying at the end of Metal Gear Solid 4. The only thing that would have made me cry is how much of a fucking cop out the ending is.