Have you bet Pandemic II on realistic yet?

The only region I cant infect is Madagascar.
http://www.crazymonkeygames.com/Pandemic-2.html

they do like to hold out, I have only once wiped out the world.

I infected madagascar. What I did was- I immediately removed all symptoms, then just left it running for about an hour or so. That way, I accumulated ~100 DNA points, but only infected 20-30 people. Then, I quickly purchased everything that would propagate the disease faster (some of the low-level symptoms, + all resistances). Madagascar got infected (by chance, I guess), and somehow my bacteria became immune to vaccine. Then I just bought the killing symptoms, and wiped out the population of earth. 

I killed everybody except Cuba. Damn island nations :(

I always kill almost everybody except an island somewhere.