Hey just looking for people who are forced to play video games with one one hand. I was born with Cerebral Palsy and only have use of one hand to use with my 360 controller. What kind of games do people play and how do others do it. A lot of my friends and roommates play 1st person Shooters like the Halos and the Call of Duty games and games like Street Fighter IV. I am at a distinct disadvantage with both. Any suggestions?
Although this might not be of any help with the games your friends are playing, there are games on the PC which can be played nearly entirely with the mouse. Games like World of Warcraft and Dragon Age: Origins can be played by used the mouse for movement and camera control then clicking the spell/action bar for attacks and so forth. Strategy games also work well in this manner. You might not (I don't know for certain) be able to compete with others in PVP scenarios, but you should work fine when playing co-op.
Was it bad that the title led me to believe this thread was about masturbation? Is it bad that I clicked on it anyway?
If you're looking to be competitive with other players you might want to try Civilization Revolution. It's turn-based so you don't have to rush to try to keep up.
Adventure games and turn-based RPGs seems like the best options for a one-handed player. If you are looking for something competitive to play with friends, you might want to try a head-to-head puzzle game. If your friends like Street Fighter, they might be up for playing Super Puzzle Fighter. You should able to rotate and drop the pieces in that game without too much trouble. You can download a demo of it on XBLA if you have your doubts about it. Word games like Quarrel tend to be more about what you know than how fast you are, so they are worth a look as well.
Not sure how much functionality you have in your weak hand, but if you're looking out for one-handed games specifically because you have trouble with traditional controllers, take a look at the Avenger Controller adapter for PS3 and 360.
Here's a vid of it being demoed at PAX 2011 (ignore the douchebag)