I'm sure there have been other threads about this, but I wanted to give my own preferences in hopes of getting more targeted answers. I know there's a lot of text here...
Here's the podcasts I currently listen to:
Giant Bombcast (of course!): It's obviously not a surprise that this is my favorite podcast. I love the wealth of knowledge the cast has, as well as the humor. Everyone seems casual. There's no awkwardness from someone trying to be too "serious" or stick to an exact schedule. And they talk about games I care about (especially PC games).
PC Gamer Podcast: This is my second favorite, because I'm primarily a PC gamer. The cast isn't (as a whole) as solid as of late (especially since Dan Stapleton left). However, there are still great people on it, it's still done well, and it is all about PC games, which I'm most interested in.
Weekend Confirmed: This is my third favorite. I like the cast (though some of them can a little too obstinate at times), and they talk about games in an intelligent and fun way. Again, they also talk about PC games, which I really appreciate. Really love the Jeffs!
PC Gamer UK Podcast: Another PC games podcast. I find some of the cast a little awkward, and the conversations are not always very humorous, but they generally talk about games I care about and have some funny moments. It only comes out once or twice a month, though.
Rock, Paper, Shotcast: Another PC gaming podcast consisting of a British cast. Generally, I have the same feedback for this one as the PC Gamer UK Podcast. RPS is even more rare than the PCG UK Podcast. It's also shorter, which I actually like. I don't really need/want more 2+ hour podcasts. :)
And I used to listed to...
IGN Command Prompt: It was their PC games podcast, but it's been dead for 2 years. I just wanted to mention it, in case anyone here remembers it. They had some great conversations and was very similar in tone to the PC Gamer (US) Podcast.
The GameSpy Debriefings: This is another dead podcast, but I found it informative and pretty entertaining. It was mostly due to the cast that were well informed and had opinions I trusted. They also spoke about PC games quite a bit. They did get a little silly at times, but it generally didn't get too bad...
Okay, and here are podcasts I've tried but just didn't appeal to me:
Eight-Four Play: I have a lot of respect for these guys, but I rarely play Japanese games. Also, the podcast can get very silly sometimes, and they tend to talk over each other a lot, which is hard for me to listen to (just a personal pet peeve of mine). Note: I'm not saying they are dumb, or that it's a bad podcast. It's just not really the tone I'm looking for.
Gamer's With Jobs Conference Call: I'm a married gamer with a full-time job. So, I can relate to that strongly. However, I didn't jive with the personalities on this podcast. Some of the humor is forced or seems too much like "inside jokes" between close friends. Also, I feel they try a little too hard to be "professional," and it can come off feeling stiff. Personally, I didn't get much gaming knowledge out of this podcast, as it seemed just to be mostly opinions (didn't seem like a lot of "insider" info from the industry), and while that can be fine, I didn't really dig it due to the personalities. Again, I'm not saying it's a bad podcast, or that the people aren't intelligent or qualified. It's just a personal preference.
CAGcast: Love this site, but, again, I am not a fan of all the personalities on the show. They also don't talk enough about games for me. In the several months I listened to the cast, I felt like I heard more about the castmembers' lives than news about games, mainly because they are focused on reviewing games and their lives as gamers, which is great, but it's just not what I'm looking for.
VGW's Unlimited Ammo: This is the podcast for a smaller site (videogamewriters.com). I decided to try it out the last few weeks. It's nice to hear some more "regular gamers" talk about games (i.e. not a major gaming journo outlet). However, I'm just not into the personalities here, either. The humor is just not my style, and I feel some of the cast is trying too hard to be funny or cynical or tongue-in-cheek.
So....given all of that, does anyone have any other recommendations you can give? I'd love it if you'd give one or two sentences (or more) on why you like the podcast you're suggesting, since that can give me an idea of what to expect.
I think I should try the @Gamer podcast and Game Informer podcast. I know GameTrailers.com has a podcast as well that I've never listened to.