Tough choices here, but I voted Max Payne 3 because I loved the first game so much, and after the stellar RDR, I have a ton of trust in R* to make it great, and in the true spirit of the original.
Maybe it's the unknown factor w/MP3 that creates that anticipation, because some of the others like ME3 or The Witcher 2, for example, are much more of a known quantity and I feel pretty comfortable guessing they'll be very good.
Are you sure we don't play as the Griffon thing in the Last Guardian? in a first person perspective so... just kidding Mass Effect 3 by far, but I do want to play some of those games , Resident Evil 6, Metal Gear Rising: Revengeance , The Last of Us, DMC, Ninja Gaiden 3, GTA V... well most of them.
Max Payne 3.
After that probably the Alan Wake XBL game, GTA V, Hitman Absolution, and MGR Revengeance.
Before playing Resident Evil 5 I probably would have said Resident Evil 6, but I just can't be excited about that series anymore despite loving it so much. I don't expect it to be bad, I just couldn't care less about it.
Max Payne 3 followed by The Last of Us, Resident Evil 6, GTA V (not really hype for it because I have no idea what it is/when it's out), Lollipop Chainsaw and...let's say Operation Raccoon City for shits and giggles (and because I kinda enjoyed what I played of the game at the preview event Capcom had a couple weeks back).
Gonna have to say Mass Effect 3, just because I'm really interested to see the multiplayer component and to see where the story ends up and how all the characters will will fit together. I would say Assassin's Creed 3 because I love 2, but that series is being driven into the ground. I'm pretty excited for Darksiders 2 though in terms of gameplay, I really enjoyed the first game. The Last of Us could be awesome as well.