I can't really decide. My top 3 nominees would be Infamous, Plants Vs. Zombies, and Batman: AA. Street Fighter 4 would follow all those closely. But I can't pick mine. At the end of the year I'll probably be adding for R&C: aCiT and Uncharted 2 to that list. If Uncharted 2 is a rather large step up from the first one it might be my pick. But let's face, MW2 is going to get GOTY from almost everywhere (though I ain't buying it).
but yeah i cant say enough about infamous, that game is so fucking satisfying. few games achieve that now but i understand why it works. sucker punch are excellent platform game developers and they know how to make a game both challenging and fun and satisfying.
Due to the lopsided nature of game releases, as well as my own personal preferences, I really haven't played much that has come out this year.
However, I will say that Street Fighter 4 is pretty awesome, even if everyone on my friend's list is better than me.