As for mine, it's just a picture of me. It's a picture that my best friend took when we went to Sausalito (where the Giant Bomb offices are located!). We had a good day, but I'm sad that I don't hear from her anymore :(
A Devil's Horns picture i took in my room using my then-new webcam... I think it looks alot more epic-er than a random snapshot in a bedroom which is why i fancy it.
You can see the iron window fence thingie through the blue curtains in a certain spot
EDIT: if you're asking about the PROFILE picture, its a screenshot from South Park: Bigger, Longer & Uncut.
You mean avatar, not profile picture.
My avatar was originally Viewtiful Joe throwing a peace sign. I said "fuck peace" and cut one of his fingers off. It's an irony of who I really am: I'm the asshole that will flip you the bird for any reason, but I'm also this lovable dood that kicks ass in his own little special way.
Plus, it just looks cool. It's Joe flipping you off!