Do any of you guys know of any somewhat similar games, but with less completely batshit crazy art? Every time I see this game in my Steam list, I want to play it, but I just can't because the art turns me off completely.
Sorry to be boring with a serious answer, but Dungeons of Dredmor is probably what you're looking for. An accessible roguelike with items that can get pretty crazy and zero poop I'm pretty sure. I think Dave quicklooked it.
This, and to be fair, there could probably be a little poop in that game we just haven't found yet.
Turn based though a hell of a lot more fun for me than Binding of Isaac was(I still play both though)