Packie because he lived with his mom yet he still manged to be extremely badass. And he has one if not thee best mission in the game (Three Leaf Clover)
Lil Jacob. He says some amazing stuff...I just reccomend subtitles. Hes the character that I acually tried to impress. And felt bad when I let him down. He was a great wing man in the last few missions
Niko, Roman, Kate then Roman's girl I forget her name though lol but yeah those were the emotional peeps in the game but if you want the comedy then of course Brucie!!!! haha
Besides the obvious of Niko, I suppose I would have to say Brucie. His lines are priceless and his attitude is hilarious. Plus he is supposed to take after FPS Doug, and that is a definite win.