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This usually happens once you have played quite far into the game, or nearing the end, partial amounts or your entire inventory will be taken away from you. Be it because you've been captured or one of many other reasons. The idea is to add a new challenge and change the gameplay for the next (or final) part of the game. In most cases, you are able to retrieve what you lost from a container of some sort after you have escaped imprisonment or completed the part of the game that involves the concept of losing your inventory.

Some famous examples of this happen during Half Life 2 (Although you obtain a new weapon in the process, the Super Gravity Gun), many times temporarily in Fallout 3 (and its DLC), Assassin's Creed (though only at the very beginning of the game) and at the end of the original Half Life (You keep the HEV suit).

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