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Dr. Fred Edison is the main villain in the videogame series Maniac Mansion.
Dr. Malcolm Betruger was the head scientist of the Union Aerospace Corporation (UAC) on Mars. He's voiced by Philip L. Clarke.
An evil scientist from the Crash Bandicoot series. Brio created the Mutagen potion, which he uses to temporarily mutate into monsters.
First appeared in Crash Bandicoot 2, replacing Dr N Brio as Dr Neo Cortex's new assistant.
Dr. X is the evil nemesis of Action Man, bent on world domination.
Eli Vance is the father of Alyx Vance and the leader of the human Resistance in the Half-Life 2 series.
Excella Gionne is the head of the African branch of the TriCell Pharmaceutical Company. She has allied herself with Albert Wesker in Resident Evil 5.
A smart Super Mutant the player can rescue from Vault 87. He is a recruitable character but only to those with positive karma. Voiced by Wes Johnson.
Officially he is "Frankenstein's monster", as the book was named after his creator, Victor Frankenstein, not the monster made of reanimated pieces of dead bodies. Nonetheless, the name stuck with the populace, and "Frankenstein" has been lumbering through horror movies and games alike for decades.
Lt. Simon "Ghost" Riley is the field subordinate of Task Force 141, an elite special forces group tasked with capturing Vladimir Makarov in Modern Warfare 2.
Gordon Freeman is the iconic main character in Valve Software's Half-Life series, and one of most well-recognized examples of the silent-protagonist.
The Male Protagonist of Mega Man ZX Advent. he is a reploid with the ability to combine with Biometal Model A to form Mega Man A.
The main character in Dead Space, Clarke is a Systems Engineer for the Concordance Extraction Corporation, sent to the USG Ishimura on a routine maintenance mission, where he discovers the nightmarish truth behind the downfall of the ship and its crew.
Isaac was an employee at Black Mesa when the Combine invasion occurred. Since then, he has been helping the resistance fight back by the only means a scientist can. By sciencing! He has a Head-Crab pet named Lamarr. Isaac Kleiner and Eli Vance are considered the leaders of the resistance.
Jack Carver is the main character in the PC game Far Cry, and in the Xbox, Xbox 360 and Wii spin-offs of the first game.
A time-traveling mad scientist and creator of the TimeSplitters.
Jill Valentine is a former R.P.D. police officer and is now a member of the B.S.A.A. fighting Bio-Terrorism around the world. She is a staple of the series.
She worked in a hidden research facility, Black Mesa East with Eli Vance. Appears in a video message in Episode 1 and 2.
King K. Rool is the primary antagonist of the Donkey Kong Country series.
Following the orders of his mistress Gruntilda, Klungo is the assistant to the witch in their fight against Banjo and Kazooie. In later games, he opens his own arcade and creates his own game.
Fighting character in the Body Blows series.
Krizalid is the boss of KOF 1999. He is a clone of K'.
A researcher who is engaged in time travel theory.
Kusanagi is an evil duplicate of Kyo that was created by the Yata Mirror.
Kyo-1 Is a clone of Kyo Kusanagi that was created by the NESTS Cartel.
Kyo-2 Is a clone of Kyo Kusanagi that was created by the NESTS Cartel.
The star of the Tomb Raider series and one of the earliest female video game protagonists. British treasure hunter Lara Croft has become one of the most widely recognized game characters in history.
Lisa first appeared in DOA's volleyball game, but appears in Dead or Alive 4 as the mysterious luchadora, La Mariposa.
Dexter's genius rival and arch nemesis and in love with his sister. He is pure evil and will do anything to destroy Dexter and his lab.
Captain of the 12th division in the Gotei 13. In the name of Science, this man is willing to go to unmentionable lengths. His zanpakuto is called Ashisogi Jizou and his Bankai is called Konjiki Ashisogi Jizou. He is the current chief/president of the department of research and development. His lieutenant in the 12th division is his artficially created daughter Nemu Kurotsuchi. He has a running gag of often changing his facial appearance.
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