Lucrezia was a cold and callous woman, who always sought to further herself and ensure the safety of her own goals. She was courageous, as she pursued relationships outside the marriages she entered, and she proved caring towards her children. During Assassin's Creed: Brotherhood, Lucrezia is shown as being somewhat foul-mouthed, cursing Caterina Sforza out in public in an attempt to humiliate her.
Italic Text : denotes information relevant outside to the Assassin's Creed franchise.
Lucrezia Borgia was the illegitimate daughter of Rodrigo Borgia , and the brother of Cesare Borgia . Supposedly, she was betrothed twice before the age of thirteen. Lucrezia Borgia was born on April 18th, 1480 in a town near to Rome, called Subiaco. Lucrezia was betrothed twice before the age of thirteen, but Rodrigo Borgia cancelled both arrangements in favor of forcing his daughter into marrying Giovanni Sforza. The marriage ended when Giovanni ceased to be of use to Rodrigo Borgia. After multiple failed marriages, Lucrezia finally married Alfonso d'Este, the Duke of Ferrara, during 1502.
During Assassin's Creed: Brotherhood, Lucrezia tries to stop Cesare from forcing his father to eat a poisoned apple, telling her that he never loved her and that he was destined to have the Apple of Eden, and also choking her. Ezio Auditore da Firenze observed the proceedings from outside the window, and then intervened to help Lucrezia. After paying his last respects to her father, she tells him where the Apple of Eden is located, and Ezio reaches the Apple of Eden before Cesare manages to.
In 1506, Lucrezia was visited in Ferrara by Ezio Auditore, who again sought to gain something from her: paintings of Leonardo da Vinci's that were lost when Monteriggioni was attacked in the opening of the game. Ezio seduced her and managed to obtain the information he needed, before leaving her in a position where she could not stop him from gathering the paintings again. She then repented for her previous sins and died in 1519, aged thirty-nine or forty.