1st time = Male Soldier; 2nd time = Female Infiltrator
 
Working through the ME1 again as a Female soldier, when I import her into ME2, probably going to play as an adept.

Three times. Played a first as Vanguard, then an Infiltrator, and finally as a Soldier. Started at Veteran then increased the difficulty on each subsequent playthrough.  It ended up being a lot of fun and had fairly different experiences each time.

33 times. period. 33rd playthrough was happened due to new DLC (alternative appearance pack 2). at least, I have one more to play for very last DLC before ME 3. I know this is too many. I can't even believe myself. crazy little bit. but this game proved the best. 

Just once. I tried playing both games through again, but honestly it was SO boring for me the second time.

Once.

On my 4th or 5th play-through I believe. Samuel L Shepard will lead me to victory!

Three times. Vanguard, Adept and Infiltrator.

Once for me. I planned two or more playthroughs but i beat it in pretty much two sittings doing all the loyalty missions and almost all of the side stuff, mineral mining included. After that I just felt so burnt out on the experience that I could never bring myself to pick it back up. Probably won't for a long, long time either.

Once but I will be doing it again after I beat some games and play though ME 1 & 2 on my 360. I have played them on my PC but I want a 360 save for when 3 comes out.

Five times.  Two times with a soldier, three times as adept.

I can't actually check, but assuming my memory is right... fourteen Shepards are on my PC back home. Each is a completionist playthrough of both games, with varying romances and surviving crew member rosters by the end of ME2.

Thrice! 

Thrice at least.  One as soldier, one as pure biotic (that was awesome), and one as infiltrator on insanity.  Planning on a fourth after I redo a ME1 playthrough with a different universe state, as a different class from the mentioned three.

half way through my seconds playthrough

Twice as usual. One time fluffy-shiny hero, one time psychotic suicidal bitch. I was thinking about a third "in between" play-through by never using the red/blue dialog options and balancing the regular ones. Maybe I should do that soon, just to see how it goes. It has been a while …

 
Twice. Once as a Infiltrator, and once as an Engineer.

0 still waiting to get it back from my  friend 

Generic male Shepard- soilder continued from ME1 mostly good
Custom lady Shepard- vanguard started from scratch all paragon 
I may do one more playthrough as a sentinel or another class

Once was enough to be honest. Good game but far too long for a second playthrough - I have other games to play and...well, there is work lol

5 or 6 times, 3 diff classes (Soldier, Vanguard, Infiltrator) and romanced different characters.

4. 5th time coming soon

Twice.
 
First on hard, right after that on insane. I've gotta say, the second run kinda revealed the many weaknesses of the game for me. It really felt like I'm running through a mediocre shooter with great characters.

Somewhere between 4-7 times. 
Probably closer to 4-5, maybe just 4. My memory sucks.
 
My first as always was my personal canon "paragon soldier"
Second was full renegade 
My final was on insanity
I know I did between 2-3 for more achievements but I never remember if I'm recalling ME1 or ME2
because I played ME1 around 8-9 times for all the achievements

I'm on my second (paragon) playthrough... i might play through the game a third time before ME3 releases.

 Three times I think... Some day before I get ME3 I'll finish my fourth playthrough to finish off my proper pick of consequences for the last installment.
...Still considering deliberately killing off some of the more annoying characters, just in case, but I'm not sure I will follow through on that...

Treis.

Only twice so far.  Working on making it THRICE.
 
Import paragon male Shep Soldier on Veteran. (slighly imperfect ending)
Import paragon male Shep Vanguard on Harcore.  (perfect ending)
Currently playing non-imported Renegade femShep Infiltrator on Insanity. 
 
Realising that Jennifer Hale is, in fact, awesome, I have gone back and played ME1 a fifth time to bring a femShep through. 
 
I don't have a Mass Effect problem. I can quit any time I want.

4 or 5 times. 
Once as Vanguard and 3 or 4 times as infiltrator, replaying after a few DLC comes out.

3. Now ask me how many times I've beaten Dragon Age.  Actually... it's also 3, but I have many more saves halfway through the game.

Nonce.

Thrice!

What the hell is wrong with you people?
 
Once.  That's the save I want to carry over into ME3, warts and all, even if I would go back and change some things.
 Going back and molding everything into what I want the state of the universe to be seems like it would cheapen many of the tough choices I had to make.
I don't want to ruin the magic.
 
Also, the game is a third-person shooter that isn't good enough to warrant making me want to play through again based solely on gameplay alone.

Only twice.  Still need to go back & do the Insanity mode.

" @FluxWaveZ:  More transparency in the story, specifically choices and their impacts= less immersion in the story from me. "

" @yinstarrunner said:

" @FluxWaveZ:  More transparency in the story, specifically choices and their impacts= less immersion in the story from me. "

Sure, but you were talking as if those who play through the game again are making their initial playthrough irrelevant for the sake of the new one. "

Four times here, I am actually running through it a 5th time to before the new dlc comes out.

Once.  Haven't felt compelled to play it a second time.
 
@FluxWaveZ said:

" @yinstarrunner: Oh, I definitely understand that. I feel like dismissing the choices you made or the events that happened during your character's story simply because one's not happy with what happened does a disservice to one's own experience. "

All in order. 
 
Infiltrator - Main run, paragon, Male, Tali relationship 
Sentinel - paragon, female, Garrus relationship 
Vanguard - renegade, male, poked Sha'ira, Liara, Jack, and Miranda 
Adept - renegade, female, slept with Sha'ira, Liara, and Jacob 
Soldier - bi-polar (Renegade in ME1, Paragon in ME2, planned renegade run in ME3) Male, relationship with Ashley and Jack (expecting conflict in ME3) 
 
Currently playing as a female bi-polar Engineer. Played paragon in ME1 and playing renegade in ME2 with a planned paragon run in ME3. So far every run has been unique and fun to play. Soldier run was probably the strangest cause by the time I got there I was so used to being a class than can debuff enemies. Shooting shit and relying on squad mates to debuff was such a weird and foreign thing to me.

Thrice. On my fourth play through on insanity.

Once. I wasn't impressed with the recruitment story enough at all to warrant additional playthroughs. A far cry from the 5 or 6 I completed of Mass Effect.