As huge fan of the series, this is a question I often struggle to answer. On the one hand, I think the story beats in Mass Effect 1 are not just vital, they're very enjoyable. Unfortunately, Mass Effect 1, especially in hindsight, plays horrifically. Mass Effect 2 and 3 are simply far more fun to actually play, moment to moment, in my opinion (not sure who would argue that though, honestly).
The stuff that carries over from game to game isn't inconsequential either. I played ME 1 on PC, but played ME 2-3 on Xbox 360, and it's extremely jarring to see a person, for instance, whom you may have chosen to let die in the first game, totally show up in the next game. It's not a completely inconsequential aspect of the game. It depends on what kind of person you are, but it definitely bothered me more than I thought it would. (Let's just say I really didn't like Ashley)
I would say, if you can muster it, try to knock out ME1. Even if it means mostly main lining it, if for no other reason than to see the major plot points and make the major decisions yours. Obviously, you should also stick to the same platform, for that reason.
It really just boils down to how much those things matter to you. At absolute minimum, I'd look over a ME1 story wiki or something. I imagine a lot of the things in ME 2 and 3 would either have far less impact, or just flat out not make sense if you don't play ME1.
It's just really hard to say. I'd say give ME1 a try, and if the combat doesn't bother you, just finish it. It's possible ME1 wont seem so bad until you play ME2. Personally, I just can't judge ME1 with out thinking about ME2. I'm never not going to remember how poorly ME1 plays compared to 2 and 3. It may not bother you though, so give it a try. Crappy combat and inventory aside, ME1 still has a fantastic story. It does far more to flesh out the universe than either ME2 and ME3.
Basically, I can't imagine enjoying the series as much as I did if I never played ME1, but obviously, I have no way of knowing that definitively.
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