First let me offer the preface: I have ME on steam, but ME2 on PS3. This means my save file won't carry, so excuse me if this problem is addressed by that wonderful feature.
So, in preparation for Mass Effect 3 (as I'm the kind of terrible person who'll wait 'til I can buy it with the DLC, so I have plenty of time), I've started the first one again. Booting up the character creator I carved myself a Sole Survivor, a back story which I'd found intriguing in ME2 but had yet to try in the original. To my delight the first game is much better at bringing this up at every occasion possible. Linking side-quests and dialogue options in seamlessly. Well, actually that's a lie. It makes it glaringly obvious that it's pandering to your particular story, but it's nice that they're acknowledging it nonetheless.
ANYWAY, I'm off on the Sole Survivor specific sidquest (Newton system), and I run into my old buddy Toombs. He's a pretty simple guy really, but he has a lot to say about Cerberus. Namely that they caused what is probably the most traumatic event OF YOUR LIFE. THE EVENT WHICH YOU NOW INESCAPABLY BLAME YOURSELF FOR EVERY DAY. THEY MURDERED YOUR FRIENDS.
Now I know through repeated trial that all dialogue options in the second game lead to "Well, I guess I'll have to join Cerberus then." However, those of you with saves, does Shepard acknowledge at all that his new employers are basically the people he's (presumably) been trying to track down and destroy throughout this process of saving the galaxy? It just seems slightly odd that he's so at ease with the situation, given how much he should (theoretically) hate their guts.