As much as I hate to think about it, this seems like a question that fans of the series should contemplate.
Most of the writing team from the original ME1 has left Bioware, and we've seen what the new generation is capable of. EA seems to be the one calling the shots regarding development cycles and that seems to have had a very detrimental impact on the final product. After DA2 and now ME3, I just don't get the feeling that Bioware is capable of handling a complex IP that requires attention to detail and consistent quality of writing.
Finally, the state of the IP's cannon is a shambles after ME3's ending, and seems to be un-salvageable. I used to think that the Mass Effect universe was the perfect set up for an MMORPG, squad RTS, or any number of game types. Now it's like, what's the point? If the developer is not going to take their own fiction seriously, why should anyone else?