I have always thought that the best medium to adapt the mass effect franchise to outside of video games would be a tv series Here are my ideas for what a Mass effect TV show could be:
The mass effect mythos is incredibly rich and I think making the show a space opera would limit the potential for fleshing out the universe in interesting ways. What interests me most about the universe is the interactions (especially personal) between species and humanities sudden emergence on the galactic scene.
To best explore these aspects I think a show following the first (or one of the first) humans to join C-Sec on the citadel. It wouldn't be a standard police procedural like law and order (although elements of these could exist), it should be the C-Sec agents responding to small disputes between inhabitants of the citadel and sort them out.
Although I would be completely shocked if a Mass Effect TV show even came close to production I think its still something to think about.
What are your guys thoughts?