Quick synopsis of the appropriate information after brushing up myself (not really any spoilers): Naked Snake (A.K.A, Jack, A.K.A. Big Boss [soon enough]) is a super fly spy man in FOX, a part of the CIA. He was trained by The Boss, a super fly spy woman. In MGS3, the OG Boss defects to the Russians and it's Snake's job to take her down. He does so and thus earns the title of Big Boss.
Soon after, Zero (your commanding officer in MGS3) comes into possession of the Philosopher's Legacy - a pot built between nations valued at 1.2 trillion dollars - with the help of Ocelot (A.K.A, Revolver Ocelot). Zero founds "The Patriots" (A.K.A., La-li-lu-le-lo, A.K.A., Cipher), a shadow organization meant to govern the world. Think illuminati. Big Boss joins the outfit, at the behest of Ocelot. Big Boss sees it differently than Zero - as a tool of peace, to carry out the dream that his former mentor held. Big Boss becomes a public figurehead of the organization, so much so that Zero felt that he needed a back-up plan if Big Boss ever defied him. So he took his DNA and cloned him 3 times: Solid Snake (our protagonist in 1 and 4), Liquid Snake (our antagonist in 1 and 4), and Solidus Snake (our antagonist in 2). When they talk about how two sons were born, they mean Liquid and Solid (Solidus is born later). EVA, a spy from MGS3 and former flame of Big Boss, is the surrogate mother for these clones.
Shortly after that, Zero and Big Boss have a massive falling out, so much so that Big Boss leaves The Patriots with the intent to destroy them. He founds the Militaires Sans Frontiers. This organization is an altruistic PMC that provides military force for those in dire need of it, and has the dual intent of combating the immense influence and power of The Patriots.
This new game will be following shortly after the events of Peace Walker, which was - shall we say - a bit of indirect foreplay before the main clash between MSF and The Patriots. The boy in the cage is Chico, a young soldier that was in the MSF in Peace Walker. The young girl the scarred man talks about is assumedly Paz (Full name: Pacifica Ocean), a young girl also in the MSF. For a bit of additional, spoilery context to the trailer, At the end of Peace Walker it is revealed that
Paz is a double agent working for The Patriots, or cipher as they go by in that game.
It appears that Snake has come to rescue them both from a new and entirely mysterious organization called XOF - FOX backwards.
As for the series timeline, it goes MGS3 (1964) >Peace Walker (1974) >Ground Zeroes (???) > MGS1(2005) >MGS2 (2007-2009) >MGS4 (2014). You should give 'em a shot! In order if you can.
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