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Offered as a reward in exchange for taking on the Peace Walker mission, Mother Base was repaired and upgraded by the efforts of Big Boss and Kaz Miller to serve the war efforts of their new mercenary group, Militaires Sans Frontieres. New recruits would be sent here to contribute to the development of weapons, work in the kitchen, act as doctors in sick bay, provide mission intelligence, or be organized back into combat teams for MSF's international missions.

Mother Base would later become the home of Metal Gear ZEKE.

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