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Nuka-Cola is a drink in the Fallout Universe.  It was the most popular drink before the war that created the wasteland, and still is in recent times. Even though now you can only find Nuka-Cola that is flat and warm (the atomic bombs destroyed most refrigerators.).
It was created by John Caleb-Bradberton (an amalgamation of the inventors of Coca-Cola (John Pemberton) and Pepsi (Caleb Bradham ) in 2044 and it has appeared in all the Fallout games (bar Brotherhood of Steel, in which it was replaced by a real world drink Bawls).
The ingredients of Nuka-Cola are Carbonated Water, Caramel Color, Aspartame, Phosphoric Acid, Potassium Benzoate (To Protect Taste), Natural Flavors, Citric Acid and Caffeine. What gives it the unique flavor is the essence of seventeen different fruits mixed in just the right proportion to give the beverage its trademark taste.

Nuka-Cola Quantum.

Currently there are four varieties of Nuka-Cola.  Standard Nuka-cola, which is plentiful and can be found within vending machines, buildings and generally all over the wasteland.  This type of Nuka-cola will give the player 2 rads and 12 health.  Nuka-Cola Quantum (introduced 2077).  The bottle and drink  glows bright blue due to a radioactive strontium isotope, designed to make the bottle stand out on a shelf.  This is much rarer in the game, with only 94 bottles to be found.  It grants you 20 action points, but also increased negative side-effects. The company also created Cherry Nuka-Cola, but nobody liked the new taste. This resulted in a marketing disaster for the company, which quickly attempted to save the brand by introducing the Classic Nuka-Cola, tasting exactly like the original but in a new bottle.

There is also a fifth type of Nuka-Cola in Fallout 3, Nuka-Cola Clear, but the product had only just finished development when the bombs hit and was never produced.
 
A sixth and seventh type appear in Fallout: New Vegas. They are called Nuka-Cola Quartz and Nuka-Cola Victory. Quartz's appearance is similar to Nuka-Cola Quantum, but instead of a blue glow it is an off-white/cream color glow. Nuka-Cola Victory also has a distinct glow, but it is a bright orange color.

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