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The final boss. Players will only encounter one Patriarch per game after the final wave of specimens. He is the most powerful and heavily armed specimen in the game, brandishing a gatling gun, powerful missile launcher, and tentacle melee attack. He also has the ability to cloak, flee, and use medical syringes (up to three times when severely hurt). When he uses his medical syringes, Clots, Crawlers, and Stalkers spawn. 
 
A little backstory on The Patriarch: His name was Kevin Clamely, and he worked at Horzine. He went insane after his son died, and created the Zed.
 
 

  • During the "Twisted Christmas" event, The Patriarch was reskinned into Santa, with Christmas-themed taunts like "You've been bad little boys and girls!"
  • During the "Summer Sideshow" event, The Patriarch was reskinned into The Ring Leader.

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