Following Sony's Gamecom conference, you can easily say that 2011 is stacked. 
 
Sony will bring you these exclusive titles:
Killzone 3
Resistance 3
Infamous 2
Socom 4
Motorstorm: Apocalypse 
Ratchet and Clank: All For One 
Yakuza 4
The Last Guardian (probably)
Final Fantasy Versus 13 (probably)
 
Microsoft and Nintendo usually announce their games closer to the release date. 
 
For 2011 we can expect from the both so far:
 Zelda: Skyward Sword
Gears of War 3
Codename: Kingdom (probably)
 
You still have all the motion control games for Move and Kinect , the launch of the 3DS and the downloadable games.
 
Then the Multiplatform games:
Rage
Mortal Kombat
MVC3
Portal 2 
Dragon Age 2
LA Noire
Batman Arkham City
 
I am probably missing some games but remember we thought 2010 was going to be a crazy year for gaming, 2011 looks even better.