@rayeth: The problem lies with the fact that many fonts are unhinted and Chromes renderer is using old school font smoothing. The problem does not show up at small sizes but in medium font sizes things can get really nasty. OS X, iOS, Windows IE/FF, Windows Surface, and Android all use better smoothing which does not need the specific hinting for things to look nice. Currently typekit has to manually hint these fonts, but they don't do it for all the weights. I've been going through and making changes just for Win/Chrome to fix this but its been a bummer for sure. And unfortunately for my sanity they don't have a way of showing which fonts have been hinted. You just have to notice during development or by looking at their screenshots.
More info on this: http://www.smashingmagazine.com/2012/04/24/a-closer-look-at-font-rendering/ Just go to the WINDOWS: UNHINTED FONTS title half way down the page.
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