KOTOR 3. After SWTOR i doubt BioWare are very keen on another Star Wars venture and Obsidian are busy with their kickstarter project (not that I think EA would consider working with Obsidian. As I understand it Disney pretty much handed Star Wars video game rights to EA). I'd still love to see a Star Wars RPG that has no affiliation with the established timeline in the movies. The first two KOTOR games did a great job of deconstructing Star Wars and on a whole were much more interesting than the movies from the same time.
I'd also want to see a sequel to Red Dead.