1. Metal Gear Solid
A great blend of Metal Gear 2 and Metal Gear Solid game mechanics. This is also the game that justified my ownership of a Gameboy Color.
2. Super Mario Bros. Deluxe
The definitive version of Super Mario Bros. it also includes Lost Levels and some fun challenge and multiplayer modes.
3. Kirby Tilt 'n' Tumble
My favorite of the Kirby spin-offs and may now be able to be ported due to the 3DS tilt sensors.
4. Wario Land II
Honestly the most challenging game in which the protagonist is invulnerable.
5. The Legend of Zelda: Oracle of Ages
The only top down Zelda games I haven't played.
6. The Legend of Zelda: Oracle of Seasons
Not counting that shitty CD-I game where you play as Princess Zelda.
7. Pokémon Pinball
A solid pinball game that was like crack to me because you literally caught and evolved Pokemon to get high scores.
The prequel to one of the few good DSiware games. Stupid name but all around solid 2-D platformer.
9. Wario Land 3
Having played every Wario game except this one is driving me crazy. Oh and yes I have played the Virtual Boy one at a Toys R' Us and would love to see that on the Virtual Console.
10. Mario Golf
This is the first golf game I ever played and it is still my favorite. I love how the single player game isn't just a tournament but an rpg-lite story mode.