Does it have to be a shooter (sort of echoing the Batman:AA question above) and does the backpack-shooting have to be a core staple of gameplay?
If "no" and "no" then I would submit the WoW:Cataclysm quest where you have to zap some orc flamethrower backpacks to take out otherwise difficult enemies. Only lasts for one quest, but does fit the concept!
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