I'm not saying it's Shenmue, because I'm not insane. But, if I were insane and predict it was Shenmue I'd use the following argument: 1) "series of massive significance" - A series, so more than one game has been release, very influential and maybe even groundbreaking at the time. 2) "Finally being confirmed" - whatever this game series is, it's taken a long, long time to get the newest instalment confirmed. 3) Ah, I've misread the last piece of the scan and thought it said something else, rendering point 3 irrelevant. Nice.
Back in the real world, a new Syphon Filter or Colony Wars would be cool, I think. Demons' Souls would be interesting, but why bother when Dark Souls 2 is going to get all the media attention soon?