The opposite choice hinges too much on the Fireflies being capable enough to carry out the nearly impossible series of events that would need to occur for this theoretical cure to actually mean anything.
So yeah, I'm with Joel. Definitely a favorite ending to one of my favorite games of all time.
Maybe consider the fact that even after the layoffs, GB still has a smaller staff then GS. Really if GB had to lay anyone off, it would be Matt Rorie. Obviously video dudes are safe (even Alex, as Vinny would have to do solo quick looks without him), and Patrick, as he's the only news guy, but as much as it hurts to say, Rorie probably has the smallest role on the site.
I think recent events have shown that Rorie is absolutely essential to the long-term health of the site.