There is no way you will get Jeff Gerstmann and Ryan Davis to sit down in a podcast booth and discuss more Mass Effect 3. And I totally don't blame them. Even as a long-time fan of the series (and as someone who doesn't give a shit either way about the ending), I just want that game to go away.
So ready for more Borderlands. Also, Gearbox released a "love letter" to PC players claiming that all of the issues from the first game's port will be addressed in the sequel. Whether that actually happens remains to be seen.
As other people have mentioned, having Rorie as a guest on the Bombcast would be cool. I'd like to at least know what's next for the guy, even if whatever that is is completely unrelated to Giant Bomb.