Not sure how much it lines up with your tastes, but I'd recommend Atomic Robo to nearly anyone. In fact, just this week, the creators announced it's now going to be going up for free as a webcomic on their site here. They're going to be uploading 3 issues every Monday/Wednesday/Friday until they catch up, and then all the new stuff is going to be uploaded there.
The best way I could describe it is an Action/Comedy about Action Science that has self-contained volumes that take place over a robot's 80+ year life. It's written by Brain Clevinger (if that means anything to you).
Only other thing I can think of is Morning Glories, which I'm struggling to try and describe besides "A bunch of kids get sent to a school and then get cut off from the outside world. It gets crazy." A Mystery/Thriller I guess, with teenagers. Largely avoids teenage melodrama though, if I'm remembering right.
As someone that actually did learn more toward DC (I haven't been keeping up with comics for a while), you're largely better off with having watched the cartoons. Batman: The Animated Series through Justice League Unlimited are arguably better than almost anything DC has ever done, especially in the case of using a lot of characters better. Only thing I can recommend there that a lot of people may not have read is the 1980s Justice League International run written by Keith Giffen and J.M. DeMatteis.