As a mainly melee focused player with some points in INT and FTH so I can use soul arrow and lightning bolt, Shrine of Amana was a Nightmare. I had to manually try and lightning bolt those bloody casters which could hit you from way too far away, because I couldn't get close enough for the target system to work. Iron Keep on the other hand, was a cake walk. I even beat the boss on my 2nd try. Hardest boss so far was the Dukes Dear Freja, but I haven't beaten the final boss yet because I wanna take out the Ancient Dragon and Vendrick.