Easiest way is grab a bus and use it to block off the bridge. Fire a shot in the air when you feel there are enough cars for the achievement. When you fire the shot people will run out of their cars and leave them empty on the bridge. This makes it far easier because when something explodes in the game the pedestrians will try to drive off. Throw a few grenades in the huge traffic jam and you should be able to get it.
It took me a grenade and a RPG blast. Its a relatively easy achievement.
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