I like South Park, I like RPGs, so I'm cautiously optimistic. I'm not entirely sold that this will be a chocolate and peanut butter situation though. I think RPGs work because they are (or at least in their prime were) some of the best delivery systems for video game worlds and narrative, and I'm not really sure this is a world I care to invest that much time in, other games have tried to make humor RPGs and I've usually found it boring. Also I'm concerned the humor won't hold up throughout the whole experience.
I think as people who work on the internet and frequently deal with internet reactions, that in most situations where the internet freaks out they are much more likely to automatically side against that opinion. You kind of have to treat the internet as the most hyperbolic being in existence, but that doesn't mean it doesn't have fair points sometimes. Specifically during the Jennifer Hepler debacle one of them said "You don't need to play games to write a game" or something along those lines, and I strongly disagree with that statement.
Also when Tekken Tag 2 came up and Jeff was pretty positive about it, but Patrick said "It says something about a franchise when it feels like you had a game that came out six months ago, even though it's been 3 years." I was really annoyed Jeff didn't call him on that, there was a Tekken game six months before that, made by a different team, that sucked, and Tekken as a brand took a hit despite their team not having any involvement.