I don't think I've seen anyone say it, but Trauma Center: New Blood for the Wii has consistently evoked laughs drunken and sober alike from my group of friends.  The degree of camp in that story is unparalleled.  Strange Christian undertones combined with some seriously screwed up pseudo-medicine and hilarious ailments (bear attack, anyone?) make this game the funniest I've had the pleasure of playing.  The cut-scenes alone don't make it though.  Co-op with a group of friends and few drinks makes the fast-paced play all the better.  It's to the point where all of us use the various hand signs of the doctors.