Games have massive and varied audience, poor behaviour from various sections of that audience is inevitable and unsolvable. Best you can realistically hope for is for people to try and simply lead by example and for the more negative crowds to be marginalized as non representative.
There's an abundance of assholes the world over who also watch movies, doesn't make movies toxic. They just don't have a microphone that broadcasts across half the planet while they watch it.
I'd like to see the original come along for the ride. I have the PS3 version digitally but I never got around to playing it, don't have the will to drag that machine out of whatever tub in the shed it's sitting in just to play it.
Honestly after Inquisition and ME3 my expectations for this game are somewhat tempered. ME3 was a rushed bungled mess with major last minute plot changes and Inquisition was the most paint by numbers RPG factory game I'd seen in while.