I personally wouldn't enjoy very much of that run, but this seems like a great idea. Also yes playing RE6 for yourself is quite important (A lot of people led be to believe that RE5 wasn't very good but I played it and it was one of the best games of the year for me. I still think RE6 is a piece of crap though.)
Dark Souls. I rage quit when the butterfly looking boss killed me when I had a spare 17000 souls and 8 humanity. I can still get it back but as I have barely any magic resistance that thing just destroys me.
When I got 100% Cliffs of Dover on expert (Guitar Hero 3). I have the scars to prove it (I literally cannot play Guitar Hero anymore). And the term Epic Win is dumb as hell.
Edit: I thought I should clarify. On the run where I achieved 100% everything went well, I was so happy I had finally done it, but I then realised what had happened. My pinky had completely locked up, so instinctivlely I used my other hand to move it. It was a sharp quick pain and my pinky has never been the same. Now whenever I straighten my pinky it locks in place and I have to conciously focus on moving it back to normal.